substance dependence refers to a diagnosis of an adolescent (or adult) who must show a maladaptive pattern of substance use for at least 12 months, accompanied by three (3) or more significant clinical signs of distress tolerance (the need for increased amounts to achieve intoxication), withdrawal (cognitive and physiological changes upon discontinuation of the drug), and other indices of compulsive use. Substance dependence is also characterized as with or without physiological dependence (i.e., with or without evidence of tolerance or withdrawal).
Substance intoxication refers to the temporary maladaptive experience of behavioral or psychological changes that are due to the accumulation of a substance in the body. It is physiological reaction, such as impaired judgment and motor ability , as well as mood change, resulting from the ingestion of a psychoactive substance.
substance use disorders (SUDs) refer to disorders that occur during adolescence and include substance dependence and substance abuse , which result from the self -administration of any substance that alters mood , perception, or brain functioning.