Prefrontal cortex is the region at the front of the brain important in language, emotional expression, the planning and producing of new ideas, and the mediation of social interactions; anterior portion of the frontal lobe of the cortex, which responds mostly to the sensory stimuli that signal the need for a movement Moreover, Prefrontal cortex is the region in the frontal lobe that is involved with executive functioning; the very front of the frontal lobes; involved in sense of self, reasoning, and planning.